An Overview of Retrosynthetic Methods, Evaluation, and Mechanism

Abstract

One particular area of chemical synthesis in organic chemistry is called organic synthesis. Chemical synthesis is a highly effective tool for humans because it yields a wide range of valuable compounds, particularly those that are either entirely absent from or present in very little amounts in nature. In organic chemistry, the concept of retrosynthesis examines the possibility of creating a complex organic molecule through the process of reverse synthesis. Retrosynthesis is an essential process for creating complicated molecules by going in the other direction—that is, breaking bonds. Rules must be followed by many principles. In order to overcome the difficulties posed by various reaction processes, concepts, and factors in organic synthesis, total synthesis, and asymmetric synthesis, "retrosynthesis" is a crucial strategy. Its synthetic routes are also simpler and easier to develop and construct. Because organic synthesis is influenced by a multitude of reaction mechanisms, concepts, and factors, "retrosynthesis" is a crucial technique for resolving its synthetic routes. It is less complex and easier to design and conceptualize than organic synthesis, total synthesis, and asymmetric synthesis.