Formulation and evaluation of losartan potassium immediate release tablets

Vinod Kumar K; Triveni A; Vikasitha B; Sri Vyshnavi D

doi:10.47957/ijciar.v8i3.209

Authors

K. Vinod Kumar Professor, Department of Pharmaceutics, St Ann’s College of Pharmacy, chirala.
A. Triveni Department of Pharmaceutics, St Ann’s college of Pharmacy, Chirala.
B. Vikasitha Department of Pharmaceutics, St Ann’s college of Pharmacy, Chirala.
D. Sri Vyshnavi Department of Pharmaceutics, St Ann’s college of Pharmacy, Chirala.

DOI:

https://doi.org/10.47957/ijciar.v8i3.209

Keywords:

Losartan potassium, Immediate-release tablets, Wet granulation, Dissolution profile, Formulation optimization, Stability studies

Abstract

This study aims to develop immediate-release tablets of losartan potassium for the fast and effective management of hypertension. Losartan potassium exhibits pH-dependent solubility, requiring careful formulation optimization. Tablets were primarily prepared by the wet-granulation method using suitable excipients. Ten formulations (F1–F10) were developed and evaluated for flow and compression properties. Post-compression tests included weight variation, hardness, friability, disintegration, and in-vitro dissolution studies. Formulations F9 and F10 demonstrated the best tablet characteristics and the fastest drug release, with dissolution profiles comparable to the marketed innovator product. Stability studies conducted at 40 °C/75% RH for two months indicated no significant changes in drug content. The optimized formulations remained physically and chemically stable. Overall, a safe, effective, and stable immediate-release losartan potassium tablet was successfully developed.

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